Break the aging code and feel 15 years younger from the inside out. In the constant battle to stay young and feel fit, we will try any of the quick fixes that come on the market, including so-called miracle products, fad diets, trendy exercise programs, and untested supplements. Many even risk elective surgical procedures just to look young again. But you don't need surgery, pricey cosmetics, or starvation to look and feel 15 years younger. The secret to living a longer, more vibrant life has at last been discovered, and the proverbial fountain of youth is right in your hands.

The completion of a consensus draft sequence for the human genome was the starting point for more thorough investigations of individual genome variation. The development of array-based strategies made it possible to look at our genome in new ways and for new types of variation to be discovered and characterized. Characterization of copy number variation and other forms of structural genetic variation has highlighted the complexity of human genetic variation and also provided significant insight into the evolution and dynamic nature of our genome. Genomic Structural Variants: Methods and Protocols provides an in-depth description of the developments in our understanding of structural genetic variation and its implications for human disease, from the introduction of microarrays up to current state-of-the-art sequencing strategies. It covers the major technologies used for research and diagnostics as well as web-based resources for variation data, and it then goes into depth regarding specific regions of the genome that differ in variation content. Specific patient groups where copy number variation has been shown to be of great importance are highlighted, and implications for both pre-natal and standard diagnostics are described. Written in the highly successful Methods in Molecular Biology™ series format, chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and accessible, Genomic Structural Variants: Methods and Protocols provides complete comprehensive coverage of this burgeoning field.

The completion of a consensus draft sequence for the human genome was the starting point for more thorough investigations of individual genome variation. The development of array-based strategies made it possible to look at our genome in new ways and for new types of variation to be discovered and characterized. Characterization of copy number variation and other forms of structural genetic variation has highlighted the complexity of human genetic variation and also provided significant insight into the evolution and dynamic nature of our genome. Genomic Structural Variants: Methods and Protocols provides an in-depth description of the developments in our understanding of structural genetic variation and its implications for human disease, from the introduction of microarrays up to current state-of-the-art sequencing strategies. It covers the major technologies used for research and diagnostics as well as web-based resources for variation data, and it then goes into depth regarding specific regions of the genome that differ in variation content. Specific patient groups where copy number variation has been shown to be of great importance are highlighted, and implications for both pre-natal and standard diagnostics are described. Written in the highly successful Methods in Molecular Biology™ series format, chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and accessible, Genomic Structural Variants: Methods and Protocols provides complete comprehensive coverage of this burgeoning field.

Classical mechanics and quantum mechanics are two of the most successful scientific theories ever discovered, and yet how they can describe the same world is far from clear: one theory is deterministic, the other indeterministic; one theory describes a world in which chaos is pervasive, the other a world in which chaos is absent. Focusing on the exciting field of 'quantum chaos', this book reveals that there is a subtle and complex relation between classical and quantum mechanics. It challenges the received view that classical and quantum mechanics are incommensurable, and revives another, largely forgotten tradition due to Niels Bohr and Paul Dirac.

After failing during the first six months of his career in sales, Tom Hopkins discovered and applied the very best sales techniques, then earned more than one million dollars in just three years. What turned Tom Hopkins around? The answers are revealed in How to Master the Art of Selling from SmarterComics, as Tom explains to readers what the profession of selling is really about and how to succeed beyond their imagination!

After failing during the first six months of his career in sales, Tom Hopkins discovered and applied the very best sales techniques, then earned more than one million dollars in just three years. What turned Tom Hopkins around? The answers are revealed in How to Master the Art of Selling from SmarterComics, as Tom explains to readers what the profession of selling is really about and how to succeed beyond their imagination!

Richly illustrated with the images from observatories on the ground and in space, and computer simulations, this book shows how black holes were discovered, and discusses our current understanding of their role in cosmic evolution. This second edition covers new discoveries made in the past decade, including definitive proof of a black hole at the center of the Milky Way, evidence that the expansion of the Universe is accelerating, and the new appreciation of the connection between black holes and galaxy formation. There are entirely new chapters on gamma-ray bursts and cosmic feedback. Begelman and Rees blend theoretical arguments with observational results to demonstrate how both approaches contributed to this subject. Clear illustrations and photographs reveal the strange and amazing workings of our universe. The engaging style makes this book suitable for introductory undergraduate courses, amateur astronomers, and all readers interested in astronomy and physics.

Contained in the immensity and depths of the Earths oceans, many of the planets species and resources thrive far away from the reaches of human civilization. With expanses that have yet to be discovered and enormous reservoirs of untapped potential, oceans provide fodder for all manners of research. This informative volume describes the features and properties of the bodies of water that make up 70 percent of the worlds surface as well as the various branches of oceanography dedicated to studying all aspects of the ocean and its life forms.

After a Soviet space station crashes into a New York City subway tunnel, a species of venomous spiders is discovered, and soon they mutate to gigantic proportions and wreak havoc on the city.

Though much of the natural world is discovered and understood, a few great mysteries remain. Consider the eel: snakelike, slimy, with a row of jagged teeth. Aside from these fearsome qualities, we know little about its life -- where it goes, what it does and how it dies. Hailed by poets as the "siren of the North Sea" and "loves arrow on earth," this shadowy creature has fascinated researchers for centuries. Now James Prosek, artist, writer and eminent naturalist, takes on the mystery of the eel, shedding light on the animal and the strange behavior it inspires in those who seek to know it.

Though much of the natural world is discovered and understood, a few great mysteries remain. Consider the eel: snakelike, slimy, with a row of jagged teeth. Aside from these fearsome qualities, we know little about its life -- where it goes, what it does and how it dies. Hailed by poets as the "siren of the North Sea" and "loves arrow on earth," this shadowy creature has fascinated researchers for centuries. Now James Prosek, artist, writer and eminent naturalist, takes on the mystery of the eel, shedding light on the animal and the strange behavior it inspires in those who seek to know it.

Though much of the natural world is discovered and understood, a few great mysteries remain. Consider the eel: snakelike, slimy, with a row of jagged teeth. Aside from these fearsome qualities, we know little about its life -- where it goes, what it does and how it dies. Hailed by poets as the "siren of the North Sea" and "love``s arrow on earth," this shadowy creature has fascinated researchers for centuries. Now James Prosek, artist, writer and eminent naturalist, takes on the mystery of the eel, shedding light on the animal and the strange behavior it inspires in those who seek to know it.

Though much of the natural world is discovered and understood, a few great mysteries remain. Consider the eel: snakelike, slimy, with a row of jagged teeth. Aside from these fearsome qualities, we know little about its life -- where it goes, what it does and how it dies. Hailed by poets as the "siren of the North Sea" and "loves arrow on earth," this shadowy creature has fascinated researchers for centuries. Now James Prosek, artist, writer and eminent naturalist, takes on the mystery of the eel, shedding light on the animal and the strange behavior it inspires in those who seek to know it.

The year is 1976 and it is a dangerous year in the Straits of Yucatan. The man is Jack Hooks, a former cop set up by his corrupt partner and sent to jail for a drug crime he didnt commit. After being yanked out of prison with an early release deal offered by the DEA, he is sent on a do or die mission; bring down the drug trade of his former partner, Frank Rossi and his contacts. Hooks has no choice but to plunge into the underworld of marijuana smuggling by making one big run through the narrow channel that flows between Cuba and Mexico, also known as "The Eye", and into the heart of a violent Colombian drug ring. At the head of the ring is Carlos Huerta, the ruthless drug lord that is Rossis source of supply, and Jacks final objective. That is, if he can escape the jungles of Colombia before his clandestine relationship with Elena, Huertas young courtesan is discovered and threatens the lives of himself, his crew and his freedom. By: Bertie Higgins, Julian Higgins & Larry Madill

The year is 1976 and it is a dangerous year in the Straits of Yucatan. The man is Jack Hooks, a former cop set up by his corrupt partner and sent to jail for a drug crime he didn``t commit. After being yanked out of prison with an early release deal offered by the DEA, he is sent on a do or die mission; bring down the drug trade of his former partner, Frank Rossi and his contacts. Hooks has no choice but to plunge into the underworld of marijuana smuggling by making one big run through the narrow channel that flows between Cuba and Mexico, also known as "The Eye", and into the heart of a violent Colombian drug ring. At the head of the ring is Carlos Huerta, the ruthless drug lord that is Rossi``s source of supply, and Jack``s final objective. That is, if he can escape the jungles of Colombia before his clandestine relationship with Elena, Huerta``s young courtesan is discovered and threatens the lives of himself, his crew and his freedom. By: Bertie Higgins, Julian Higgins & Larry Madill

Antony Laurence Carey (born October 16, 1953, Turlock, California) is a keyboard player best known for his work with Rainbow. One of his earliest musical experiences was in a band called Blessings, in which he played until 1975 when Ritchie Blackmore discovered and hired him as keyboardist for Rainbow. He played with Rainbow on two world tours, until 1977. After his departure from Rainbow he began a solo career, releasing albums under his own name as well under the moniker of Planet P Project, and producing for and performing with other artists.